Grants Funded
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Research Abstracts
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
The Effects of Carbamylated Erythropoietin on Peripheral Nerve Regeneration
Principal Investigator
Paul Afrooz MD
Paul Afrooz MD
Year
2008
2008
Institution
University of Pittsburgh
University of Pittsburgh
Funding Mechanism
Basic Research Grant
Basic Research Grant
Focus Area
Peripheral Nerve
Peripheral Nerve
Abstract
The overall purpose of this study is to investigate the effect of carbamylated erythropoietin (CEPO) for its effect on nerve regeneration and function after peripheral nerve injury and delayed repair. Erythropoietin has been shown to profoundly improve nerve regeneration after injury in the central and peripheral nervous system, however, its hematopoietic potential poses the risk of unwanted thrombotic events. We hypothesize, that CEPO - a derivative of erythropoietin devoid of hematopoietic potential - will provide a beneficial profile of peripheral nerve regeneration after injury and delayed repair. More specifically, we investigate the effect of CEPO on the quality and velocity of nerve regeneration when the nerve endings are repaired with a delay of 3, 7 and 14 days after nerve injury.
The overall purpose of this study is to investigate the effect of carbamylated erythropoietin (CEPO) for its effect on nerve regeneration and function after peripheral nerve injury and delayed repair. Erythropoietin has been shown to profoundly improve nerve regeneration after injury in the central and peripheral nervous system, however, its hematopoietic potential poses the risk of unwanted thrombotic events. We hypothesize, that CEPO - a derivative of erythropoietin devoid of hematopoietic potential - will provide a beneficial profile of peripheral nerve regeneration after injury and delayed repair. More specifically, we investigate the effect of CEPO on the quality and velocity of nerve regeneration when the nerve endings are repaired with a delay of 3, 7 and 14 days after nerve injury.