The Plastic Surgery Foundation
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Grants We Funded

Grant applicants for the 2022 cycle requested a total of over $2.9 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 115 grant applications on the following topics:

The PSF awarded research grants totaling almost $550,000 to support 19 plastic surgery research proposals.

ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.

Research Abstracts

Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.

Spitzoid Nevi Versus Melanoma by Cellular Gp100, Nedd9 and Gab2

Principal Investigator
Matthew McRae MD, FRCSC


Yale School of Medicine

Funding Mechanism
Basic Research Grant

Focus Area

Classic and atypical Spitz nevi are uncommonly occurring melanocytic lesions with an incidence of 7 in 100,000. They most commonly present in children and adolescents but may also occur in adults. The clinical and histological features of melanoma can be similar to both the classic and atypical Spitz nevi. Spitzoid melanoma is the variant of melanoma that shares clinical features with spitz nevi. There is no single discriminating factor between Spitz nevi and melanomas as every trait of Spitz nevi has been described in melanoma. While spitz nevi most commonly occur in children, a population where melanoma is quite rare, it is estimated that 40% of children who do develop melanoma are originally misdiagnosed. As melanoma is on the differential of every Spitz nevus, differentiating between the two is incredibly important. Over treatment of Spitz Nevi can result in significant morbidity while under treatment of melanoma can result in premature death. Our hypothesis is that the subcellular localization of Gp100, Nedd9 and Gab2 will be consistently altered in spitzoid melanoma when compared to benign spitz nevi.