The Plastic Surgery Foundation
Log In Donate Now
 

Grants We Funded

In 2019, The Plastic Surgery Foundation (The PSF) awarded 33 investigator-initiated projects and allocated $891,274 to support the newest, clinically relevant research in plastic surgery.

The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.

Research Abstracts

Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area, or PSF funding mechanism.

The Influence of Innervation on Tissue Engineered Muscle Fiber Type

Principal Investigator
Melissa Melvin MD

Year
2008

Institution
University of Michigan

Funding Mechanism
Basic Research Grant

Focus Area
Tissue Engineering

Abstract
Patients with muscle loss and/or localized paralysis could benefit from tissue-engineered skeletal muscle. Using an in vivo model of directed angiogenesis in the rat, we have previously engineered vascularized, neurotized skeletal muscle flaps that exhibit structural and functional characteristics of native muscle, and have the potential for microsurgical transfer on a dedicated vascular pedicle. Being able to influence the phenotypic development (slow- or fast-twitch) of a developing muscle construct would be highly desirable, in order to engineer a specific muscle type for a specific deficit. It is well-known that specific neural innervation patterns are responsible for directing skeletal muscle fiber type development. Therefore, we hypothesize that differential neural input can direct the fiber type of tissue engineered skeletal muscle constructs.