Grants Funded
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Research Abstracts
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
The Wnt Pathway and Biomaterials in Ssurgical Wound Regeneration
Principal Investigator
Stephen R. Sullivan MD, MPH, FACS
Stephen R. Sullivan MD, MPH, FACS
Year
2006
2006
Institution
University of Washington
University of Washington
Funding Mechanism
Basic Research Grant
Basic Research Grant
Focus Area
Wounds / Scar
Wounds / Scar
Abstract
Adult wounds are repaired by proliferation and migration of multiple cell types that form a scar. Scar lacks skin appendages such as hair follicles, sweat glands and sebaceous glands; and dermal structure is contracted with variable collagen deposition. Undifferentiated cells can be found in the healing wound and can be recruited for skin structure regeneration rather than repair with scar. During embryogenesis, fate of undifferentiated cells are guided by multiple morphogens, including the Wnt gene family. The undifferentiated cells found in adult wounds can similarly be guided by Wnt genes transcription. The purpose of this application is to evaluate the effect of Wnt gene transcription on skin appendage regeneration of healing wounds. We hypothesize that Wnt gene expression will guide undifferentiated skin wound cells toward skin appendage regeneration during wound repair morphogenesis.
Adult wounds are repaired by proliferation and migration of multiple cell types that form a scar. Scar lacks skin appendages such as hair follicles, sweat glands and sebaceous glands; and dermal structure is contracted with variable collagen deposition. Undifferentiated cells can be found in the healing wound and can be recruited for skin structure regeneration rather than repair with scar. During embryogenesis, fate of undifferentiated cells are guided by multiple morphogens, including the Wnt gene family. The undifferentiated cells found in adult wounds can similarly be guided by Wnt genes transcription. The purpose of this application is to evaluate the effect of Wnt gene transcription on skin appendage regeneration of healing wounds. We hypothesize that Wnt gene expression will guide undifferentiated skin wound cells toward skin appendage regeneration during wound repair morphogenesis.