The Plastic Surgery Foundation
Log In Donate Now
 

Grants We Funded

In 2019, The Plastic Surgery Foundation (The PSF) awarded 33 investigator-initiated projects and allocated $891,274 to support the newest, clinically relevant research in plastic surgery.

The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.

Research Abstracts

Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area, or PSF funding mechanism.

Marrow Stem Cells with Skin Substitutes for Diabetic Wounds

Principal Investigator
Xiao Tian Wang

Year
2005

Institution
Boston University

Funding Mechanism
Basic Research Grant

Focus Area
Wounds/Scar

Abstract
The goal of this proposal is to use stem cells with skin substitute transplantation to improve chronic wound healing in diabetes. The hypothesis to be tested is that the performance of marrow-derived progenitor cells in accelerating diabetic wound healing may be enhanced by genetic modification to overproduce a vasculogenic cytokine. The following are the two specific aims of the proposed study: 1. To develop adeno-associated viral (AA V -2) vectors with exogenous vascular endothelial growth factor (VEGF) gene for use in transducing bone marrow progenitor cells. These genetically modified bone marrow derived progenitors will then be seeded into an FDA approved artificial skin substitute. 2. To evaluate effects of skin substitutes loaded with AA V2-VEGF gene modified marrow progenitor cells on promotion of wound healing in chronic wounds in db+/db+ diabetic mice. This work is the extension of our ongoing efforts to promote soft tissue healing with gene transfer of growth factors by extending the target cells to bone marrow progenitors.