Grants Funded
Grant applicants for the 2024 cycle requested a total of nearly $3 million dollars. The PSF Study Section Subcommittees of Basic & Translational Research and Clinical Research evaluated more than 100 grant applications on the following topics:
The PSF awarded research grants totaling over $650,000 dollars to support more than 20 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Research Abstracts
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Acellular Dermal Matrix in One-Stage Breast Reconstruction:A RCT
Toni Zhong MD
2009
University Health Network, Toronto, Ontario
National Endowment for Plastic Surgery Grant
Breast (Cosmetic / Reconstructive)
While two-stage tissue expander/implant (TE/I) technique is an excellent reconstructive option in well-selected mastectomy patients, the primary drawback, however, is that it requires two separate procedures under general anesthesia and multiple office visits for expander inflation to create the breast mound. While the effect of acellular dermis on various clinical outcomes in the setting of two-stage TE/I reconstruction is currently investigated by a multi-center randomized controlled trial led by McCarthy, the use of acellular dermal matrix in one-stage prosthetic breast reconstruction has been reported only by a few small case series. Thus, in order to rigorously evaluate the use of acellular dermal matrix in single-stage reconstructions, we propose a multi-center, randomized controlled trial designed to study patient satisfaction and quality of life (QOL) associated with the use of acellular dermis in one-stage, implant reconstruction compared to the traditional, two-stage, TE/I reconstruction. By eliminating the intermediate process of tissue expansion and converting the conventional two-stage procedure to one-stage with the use of human acellular dermis, we hypothesize thatpatient satisfaction and quality of life will be significantly improved following skin-sparing mastectomy. In addition, other important implications for successful single-stage immediate breast reconstruction include: 1. Decreasing the surgical wait-list for primary cancer cases; 2. Increasing the efficiency within the clinic; 3. Expediting the patient's return to productivity; 4. Easing the overburdened hospital OR usage; and 5. Potentially offloading the financially strained healthcare system by eliminating the cost of tissue expanders, serial expansion with clinic visits, and a second OR under general anesthesia.
To facilitate valid post-hoc comparisons between our outcome measures and those used by McCarthy et al, we have intentionally set up our research design (participant eligibility, treatment plan, surgical technique using the acellular dermis, timing of postoperative evaluations) to mirror their protocol. This will allows us to directly compare the intervention effect on QOL and patient satisfaction scores between the two studies. The conclusion generated by comparing the confidence interval of effect size, therefore, would help answer the question of whether patient-satisfaction is improved by the use of acellular dermal matrix alone or its ability to convert a two-stage reconstruction to one-stage. Therefore, our proposed study follows the natural progression of scientific research with a multi-center RCT on the safety and patient-perceived benefits derived from the use of acellular dermis in the novel setting of one-stage implant reconstruction.
