Grants Funded
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Research Abstracts
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Micro-RNA and Classification of Hemangiomas
Principal Investigator
Christopher Spock MD
Christopher Spock MD
Year
2008
2008
Institution
Yale School of Medicine
Yale School of Medicine
Funding Mechanism
Basic Research Grant
Basic Research Grant
Focus Area
Other
Other
Abstract
Hemangiomas are the most common head and neck tumors in the pediatric age group. Despite their frequency, little is known about the factors controlling their growth and regulation. We have identified two transcription factors CTCF (CCTCCC binding factor) and BORIS (Brother of the regulator of imprinted sites) that play a major role in the regulation of hemangioma growth, acting through IGF2, a critical growth factor in pediatric tumors. MicroRNAs are recently discovered molecules that are known to regulate a host of physiological functions including growth and development of tumors. We have additionally identified two microRNAs, MicroRNA23a (mir23a) and MicroRNA23b (mir23b) that are very strongly correlated to the expression of the transcription factors CTCF and BORIS, thus influencing the growth of hemangiomas. We therefore propose: 1. To formally demonstrate the regulation of CTCF and BORIS by mir 23a and 23b in an in vitro model 2. To create a transgenic mouse model of hemangiomas by over expressing microRNA 23b, using an endothelial cell specific promoter Tie-2 3. To propose a new method of molecular classification of hemangiomas based on microRNA profiles through a microarray analysis
Hemangiomas are the most common head and neck tumors in the pediatric age group. Despite their frequency, little is known about the factors controlling their growth and regulation. We have identified two transcription factors CTCF (CCTCCC binding factor) and BORIS (Brother of the regulator of imprinted sites) that play a major role in the regulation of hemangioma growth, acting through IGF2, a critical growth factor in pediatric tumors. MicroRNAs are recently discovered molecules that are known to regulate a host of physiological functions including growth and development of tumors. We have additionally identified two microRNAs, MicroRNA23a (mir23a) and MicroRNA23b (mir23b) that are very strongly correlated to the expression of the transcription factors CTCF and BORIS, thus influencing the growth of hemangiomas. We therefore propose: 1. To formally demonstrate the regulation of CTCF and BORIS by mir 23a and 23b in an in vitro model 2. To create a transgenic mouse model of hemangiomas by over expressing microRNA 23b, using an endothelial cell specific promoter Tie-2 3. To propose a new method of molecular classification of hemangiomas based on microRNA profiles through a microarray analysis