Grants Funded
Grant applicants for the 2024 cycle requested a total of nearly $3 million dollars. The PSF Study Section Subcommittees of Basic & Translational Research and Clinical Research evaluated more than 100 grant applications on the following topics:
The PSF awarded research grants totaling over $650,000 dollars to support more than 20 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Research Abstracts
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Flap Engraftment of Adipose Derived Stem Cells to Improve Vascularization
Scott Hollenbeck MD, FACS
2008
Duke University
Basic Research Grant
Tissue Engineering
Regeneration of human tissue from muitipotential stem cells is a promising option for the treatment of a wide array of diseases. The mesenchymal stem cells derived from human adipose tissue have the potential to differentiate into a variety of mature tissues including muscle, bone, nerve and fat. While there has been rapid expansion in the understanding of stem cell induction there remains little knowledge of the factors which govern adipose derived stem cells (ADSC's) interaction with the surrounding extracellular matrix (ECM). Furthermore, the plasticity of these interactions as stem cells differentiate is not known. The purpose of this focused study is to investigate the role that transmembrane proteins, known as integrins, play in ADSC attachment and migration. We hypothesize that integrin expression in these cells is dynamic, and will vary dependent on degree and direction of differentiation. Moreover, the timing and specificity of integrin expression will govern critical interactions with the extracelular environement, specifically, ECM dependent cell migration and attachment. This knowledge would contribute to the efforts to design targeted delivery of ADSC's to wounded tissue. To date, there has been little understanding of the expression and role of integrins in human ADSC' s.
