Grants Funded
Grant applicants for the 2024 cycle requested a total of nearly $3 million dollars. The PSF Study Section Subcommittees of Basic & Translational Research and Clinical Research evaluated more than 100 grant applications on the following topics:
The PSF awarded research grants totaling over $650,000 dollars to support more than 20 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Research Abstracts
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Nrf2-active bioengineered exosomes for acceleration of diabetic skin regeneration
Piul Rabbani
2019
New York University School of Medicine
Translational and Innovation Research Grant
Tissue Engineering, Wounds / Scar
Management of chronic non-healing diabetic cutaneous wounds relies on repeated invasive measures, such as debridement and extremity amputations, compromising the quality of life for patients and underscoring the need for effective therapies. We recently demonstrated significantly accelerated time to closure of murine diabetic wounds after localized therapy with murine bone marrow-derived mesenchymal stem cells (MSCs), specifically with active nuclear-factor-erythroid-2-related factor-2 (Nrf2) signaling, in comparison to untreated diabetic wounds. To elude potential unwanted growths from MSCs, we explored exosomes (Exo), secreted extracellular vesicles, that have been identified as paracrine vectors of communication among MSCs and other cells. Others have tried MSC-Exo therapy with varying degrees of success in models of lung injury, renal disease, and diabetic wounds. However, most attempts were systemic and MSC identity was broadly defined, making any molecular changes and consequent differences in Exo challenging to characterize. As the bioactive Exo cargo depends on the source cell and microenvironment, well-delineated MSC identity criteria are essential for predictable use of Exo as therapy. We found that Nrf2-mediated redox regulation determines MSC multipotency and enables their participation in wound healing. Therefore, we treated diabetic wounds locally with Exo from phenotypically-defined, multipotent, Nrf2-stable MSCs. The highly significant decrease in healing time was accompanied by increased neovascularization in the wound bed granulation tissue. Granulation tissue is a critical feature and predictor of successful wound closure, but is typically insufficient in diabetic wounds. Driven by our promising preliminary results, now we aim to apply human bone marrow-derived MSC-Exo as therapy, from source cells with stable Nrf2 signaling, and evaluate the human MSC-Exo cargo for optimizing the molecular effects on vascular cells in granulation tissue. This study will lay a foundation for development of exosome-based clinical therapy, customized to target the lack of neovascularization in chronic diabetic ulcers and promote healing.
