The Plastic Surgery Foundation
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Grants We Funded

Grant Applicants for 2020 requested more than $4.1 million. The PSF Study Section Subcommittees of Basic and Translational Research and Clinical Research Evaluated 111 applications on the following topics:

The PSF awarded Research Grants totaling more than $860,000 to support 24 plastic surgery research proposals.

The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.

Research Abstracts

Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.

Quantifying Botulinum Toxin Treatment Effect Using DISC Analysis

Principal Investigator
Alexander Dagum MD

Year
2011

Institution
SUNY at Stony Brook

Funding Mechanism


Focus Area


Abstract
The effects of Botulinum toxin treatment on facial musculature have previously relied upon subjective, qualitative patient- and physician-reported outcomes. We seek to apply a novel quantitative metric in a prospective observational study. Digital Image Speckle Correlation (DISC) analysis is a non-invasive, sensitive technique that quantifies facial muscle recruitment by detecting subtle deformations of the overlying skin. A photo is taken of a patient volunteer with the face at rest and during a slight facial movement, and the software calculates the force of contraction. DISC quantifies the initial paralysis of each individual muscle group and monitors their return of function over time. Botulinum toxin injections will be dosed to cosmetic effect in the forehead, glabellar, and crow's feet areas. Photos will be taken of patient volunteers immediately before and after treatment using a head stabilizer that standardizes position and distance from the camera, with their faces at rest and then raising their eyebrows, frowning, and blinking. This series will be repeated at one week, two weeks, four weeks, and monthly to six months follow-up. DISC software will then be used to calculate the contractile force of the facial muscles initially and at each subsequent follow-up visit, comparing to the baseline to determine the percentage change over time. We will corroborate our quantitative analysis with patient-reported data using the validated FLO-11Questionnaire and SPA Measure, as well as SGA and FWS scored by plastic surgeons. DISC is a sensitive, non-invasive measure of facial muscle dynamics that provides a novel approach to quantitative, prospective outcomes data to Botulinum toxin treatment. It has the potential to enhance clinical judgment in tailoring treatment to individual patients. Additional applications of this technology include monitoring recovery following nerve repair, or quantifying prospective outcomes data for facial transplant recipients.