Grants We Funded
Grant applicants for the 2022 cycle requested a total of over $2.9 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 115 grant applications on the following topics:
The PSF awarded research grants totaling almost $550,000 to support 19 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Micro-RNA and Classification of Hemangiomas
Christopher Spock MD
Yale School of Medicine
Basic Research Grant
Hemangiomas are the most common head and neck tumors in the pediatric age group. Despite their frequency, little is known about the factors controlling their growth and regulation. We have identified two transcription factors CTCF (CCTCCC binding factor) and BORIS (Brother of the regulator of imprinted sites) that play a major role in the regulation of hemangioma growth, acting through IGF2, a critical growth factor in pediatric tumors. MicroRNAs are recently discovered molecules that are known to regulate a host of physiological functions including growth and development of tumors. We have additionally identified two microRNAs, MicroRNA23a (mir23a) and MicroRNA23b (mir23b) that are very strongly correlated to the expression of the transcription factors CTCF and BORIS, thus influencing the growth of hemangiomas. We therefore propose: 1. To formally demonstrate the regulation of CTCF and BORIS by mir 23a and 23b in an in vitro model 2. To create a transgenic mouse model of hemangiomas by over expressing microRNA 23b, using an endothelial cell specific promoter Tie-2 3. To propose a new method of molecular classification of hemangiomas based on microRNA profiles through a microarray analysis