Grants We Funded
Grant applicants for the 2021 cycle requested a total of over $3.3 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 106 grant applications on the following topics:
The PSF awarded research grants totaling more than $755,000 to support 25 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Adipose Derived Stem Cells for Enhanced Fibrovascular Integration of Acellular Dermal Matrix-Based Ventral Hernia Repair
Charles Butler MD
University of Texas, MD Anderson Cancer Center
Basic Research Grant
The purpose of this study is to evaluate the potential for adipose-derived stem cells (ASCs) to enhance interface zone fibrovascular incorporation, vascularity and regenerative potential at the acellular dermal matrix (ADM) -fascia interface of ventral hernia repairs. The following are the goals of the study: 1. Compare scaffold pre-seeding to direct injection of ASCs into the fascia-ADM interface. 2. Quantify the fascia-ADM interface zone engraftment of ASCs over the first two weeks post-operatively. 3. Determine the phenotype of engrafted stem cells at the fascia-ADM interface zone. 4. Evaluate the functional capacity of ASCs in the setting of ventral hernia repair. Clinical problems in this setting include technical challenges in the reduction and repair of complex chronic hernias, difficulty in achieving complete reconstruction of abdominal wall elements, and significant rates of recurrence. The potential to improve current materials-based repairs with a stem cell-based, tissue engineered approach could provide a superior reconstruction at the tissue and cellular level, yielding a reduced rate of recurrence. Our hypothesis is that ASCs will enhance vascular support, tissue regeneration, and bioprosthetic incorporation at the graft-abdominal wall interface.