Grants We Funded
In 2019, The Plastic Surgery Foundation (The PSF) awarded 33 investigator-initiated projects and allocated $891,274 to support the newest, clinically relevant research in plastic surgery.
The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area, or PSF funding mechanism.
A New Protocol for Tolerance Induction to Composite Tissue Allotransplantation
Jignesh Unadkat MD
University of Pittsburgh
Basic Research Grant
Composite tissue allotransplantation (CT A) represents a novel surgical tool in the reconstructive surgeon's armamentarium. It provides a true replacement of "like for like" and does not involve any donor site morbidity. However, long term CTA survival requires chronic immunosuppression, which is associated with complications such as drug and metabolic toxicities, opportunistic infections and malignancies. To overcome the risk-benefit ratio of CTA as routine surgical reconstructive option, limiting chronic immunosuppression and preventing acute rejection is absolutely vital. The potential efficacy of bone marrow (BM) transplantation for tolerance induction is well established. Use of donor BM transplantation to induce tolerance to CTA represents an attractive option. However, its full potential has not yet been realized due to the need for recipient myeloablative preconditioning, risk of graft versus host disease (GVHD), which limits the amount of BM transplantable and risk of sensitization. Specific Aim: To use massive doses of donor BM to induce tolerance to CTA and assess the mechanism without causing any side effects. Hypothesis: The concomitant use of massive doses of donor BM in presence of co-stimulatory blockade without any recipient preconditioning along with short-ten11 rapamycin will induce robust tolerance to CTA without risks of GVHD, sensitization or chronic immunosuppression.