The Plastic Surgery Foundation
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Grants We Funded

In 2019, The Plastic Surgery Foundation (The PSF) awarded 33 investigator-initiated projects and allocated $891,274 to support the newest, clinically relevant research in plastic surgery.

The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.

Research Abstracts

Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area, or PSF funding mechanism.

Development of a Novel Bio-Integrated Peripheral Nervous System Interface

Principal Investigator
Brent Egeland MD

Year
2008

Institution
University of Michigan

Funding Mechanism
Basic Research Grant

Focus Area
Technology Based

Abstract
Trauma and disease related upper extremity amputation causes substantial disability due to functional and tactile deficits while performing basic activities of daily living, Restoration of mechanical and sensory function following amputation is critically important. To date, the development of a biointegrated, durable, high fidelity, permanent prosthesis with bidirectional neural motor and sensory function, combined with refined robotics to effect or trigger these responses remains elusive, We have developed a novel construct using the biocompatible electroconductive polymer PEDOT (poly(3,4-ethylenedioxythiophene)) on acellular muscle (ACM) scaffolds, Preliminary data has shown that this construct is capable of propagating action potentials across at least 20mm nerve gaps, We hypothesize that an efferent action potential in the peripheral nerve can be electrically detected and delivered to downstream electronic circuitry using PEDOT-ACM scaffolds with longevity and fidelity. Furthermore, we hypothesize that afferent sensory signals can be delivered centrally using the same device architecture. Our specific aims are to investigate the bioelectrical construct in regards to the following: 1) in vivo PEDOT-ACM characteristics including physical and electrical interactions with native axons, in vivo biocompatibility, and durability. 2) ability to detect an efferent motor action potential 3) ability to initiate an afferent sensory action potential through electrical stimulation.