Grants Funded
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Research Abstracts
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Primary Alveolar Cleft Healing After Gingivoperiosteoplasty and rhBMP-2.
Principal Investigator
Navanjun Grewal MD
Navanjun Grewal MD
Year
2008
2008
Institution
University of California, Los Angeles
University of California, Los Angeles
Funding Mechanism
Basic Research Grant
Basic Research Grant
Focus Area
Cranio/Maxillofacial/Head and Neck
Cranio/Maxillofacial/Head and Neck
Abstract
Our objective is to investigate the effectiveness and clinical use of rhBMP-2 to augment the repair of primary alveolar cleft defects. With the use of presurgical nasoalveolar molding (NAM), gingivoperiosteoplasty (OPP) may be done effectively with limited dissection so there is not detrimental effect on maxillary growth and 60% of patients subsequently do not require an alveolar bone graft. Bone morphogenic protein-2 is clinically available and may offer improved healing in these cases. Our hypothesis is that rhBMP-2 used in combination with NAM and OPP will improve bony healing across the alveolar cleft and further reduce the need for secondary bone grafting. Our first aim is to compare alveolar cleft healing with and without BMP-2 in a rat alveolar cleft model using a OPP with histologic and radiographic bone density assessment. Our second objective is to evaluate midface growth after primary alveolar cleft defect repair with BMP-2 in a rat model using serial cephalograms. Our final objective is to assess clinical bone healing in newborns after NAM and OPP with BMP-2 using serial radiographic studies. Our strategy of employing the osteoinductive properties of BMP-2 may improve clinical outcomes.
Our objective is to investigate the effectiveness and clinical use of rhBMP-2 to augment the repair of primary alveolar cleft defects. With the use of presurgical nasoalveolar molding (NAM), gingivoperiosteoplasty (OPP) may be done effectively with limited dissection so there is not detrimental effect on maxillary growth and 60% of patients subsequently do not require an alveolar bone graft. Bone morphogenic protein-2 is clinically available and may offer improved healing in these cases. Our hypothesis is that rhBMP-2 used in combination with NAM and OPP will improve bony healing across the alveolar cleft and further reduce the need for secondary bone grafting. Our first aim is to compare alveolar cleft healing with and without BMP-2 in a rat alveolar cleft model using a OPP with histologic and radiographic bone density assessment. Our second objective is to evaluate midface growth after primary alveolar cleft defect repair with BMP-2 in a rat model using serial cephalograms. Our final objective is to assess clinical bone healing in newborns after NAM and OPP with BMP-2 using serial radiographic studies. Our strategy of employing the osteoinductive properties of BMP-2 may improve clinical outcomes.