Grants We Funded
Grant applicants for the 2022 cycle requested a total of over $2.9 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 115 grant applications on the following topics:
The PSF awarded research grants totaling almost $550,000 to support 19 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Primary Alveolar Cleft Healing After Gingivoperiosteoplasty and rhBMP-2.
Navanjun Grewal MD
University of California, Los Angeles
Basic Research Grant
Cranio/Maxillofacial/Head and Neck
Our objective is to investigate the effectiveness and clinical use of rhBMP-2 to augment the repair of primary alveolar cleft defects. With the use of presurgical nasoalveolar molding (NAM), gingivoperiosteoplasty (OPP) may be done effectively with limited dissection so there is not detrimental effect on maxillary growth and 60% of patients subsequently do not require an alveolar bone graft. Bone morphogenic protein-2 is clinically available and may offer improved healing in these cases. Our hypothesis is that rhBMP-2 used in combination with NAM and OPP will improve bony healing across the alveolar cleft and further reduce the need for secondary bone grafting. Our first aim is to compare alveolar cleft healing with and without BMP-2 in a rat alveolar cleft model using a OPP with histologic and radiographic bone density assessment. Our second objective is to evaluate midface growth after primary alveolar cleft defect repair with BMP-2 in a rat model using serial cephalograms. Our final objective is to assess clinical bone healing in newborns after NAM and OPP with BMP-2 using serial radiographic studies. Our strategy of employing the osteoinductive properties of BMP-2 may improve clinical outcomes.