Grants We Funded
Grant applicants for the 2022 cycle requested a total of over $2.9 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 115 grant applications on the following topics:
The PSF awarded research grants totaling almost $550,000 to support 19 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Alloderm-Adipose Derived Stem Cell Constructs to Optimize Cleft Palate and Oronsal Fistula Healing
James Bradley MD, FACS
University of California, Los Angeles
Basic Research Grant
Cranio/Maxillofacial/Head and Neck
Although effective techniques exist for cleft palate closure, post-repair complications of an oronasal fistula may be problematic. AlloDerm or acellular dermis has been used successfully in a cleft palate animal model and in a few clinical cases (1). Improvement of this procedure with cellular seeding of AlloDerm may maximize the chance for healing. In our two-part study, we will attempt to develop a superior tissue engineering scaffold that can ultimately promote osteogenesis and heal cleft palate defects. 1. In our in vitro study, we will determine if AlloDerm may act as suitable matrix for adipose derived stem cells (ASCs) in promoting cell growth, aggregation, and differentiation using DNA proliferation assays and RT-PCR for osteogenic factors. 2. In our in vivo study, we will determine if an AlloDerm/ASC construct may be used to heal oronasal cleft defects in athymic rat model with histologic analysis. Our goal is to determine the efficacy of lipoaspirate stem cells (PLA cells) seeded in AlloDerm, an acellular collagen-based dermal matrix, in healing alveolar cleft defects. We hypothesize that AlloDerm will ensure homogenous ASC proliferation and distribution and promote bone growth in order to treat cleft-palatal defects. This tissue engineering strategy may then be used clinically in the operating room without the need for creation of a laboratory bioreactor.
Dr. Bradley is currently the Bernard Sarnat Professor of Plastic Surgery and Chief of Pediatric Plastic Surgery at the University of California, Los Angeles. He is also the Director of the Kawamoto Craniofacial Fellowship and Chief of Plastic Surgery at Olive View Medical Center. He is Board Certified by both the American Board of Plastic Surgery and the American Board of Surgery. Dr. Bradley received his Bachelor of Arts degree at the University of Notre Dame for Anthropology and Art. In Philadelphia, he matriculated at Thomas Jefferson Medical College where he received his Medical Degree. He then trained in General Surgery at Pennsylvania Hospital. In Manhattan, he completed his plastic surgery training at the Institute of Reconstructive Plastic Surgery, New York University. In Los Angeles, Dr. Bradley did additional training in Craniofacial Surgery at UCLA under Dr. Henry Kawamoto. In Pittsburgh, he directed the Craniofacial Surgery Program and was the Chief of Pediatric Plastic Surgery at the University for several years before returning to Los Angeles. Clinically, Dr. Bradley specializes in Craniofacial Surgery and volunteers internationally to help children with Craniofacial deformities. He is active in the bone tissue engineering laboratory at UCLA. He has published over 100 scientific papers, written over 20 chapters and edited 3 books. He also has a strong interest in not-for-profit foundation work aimed at children with facial deformities.