Grants We Funded
Grant applicants for the 2022 cycle requested a total of over $2.9 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 115 grant applications on the following topics:
The PSF awarded research grants totaling almost $550,000 to support 19 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Effect of SiRNA Against Noggin in Healing Calvarial Defects
Xiao Xia Wang MD
New York University Medical Center
Basic Research Grant
Cranio/Maxillofacial/Head and Neck
The creation of a bony defect results in a hypoxic gradient wherein the oxygen tension at the center of the defect is very low. Previously, our lab has demonstrated that osteoblasts exposed to a hypoxic environment alter their expression of cytokines, bone-specific extracellular matrix molecules, and their regulators. Bone morphogenetic protein (BMP) expression has been found to decrease significantly in hypoxia. We hypothesize that the expression of noggin, a BMP inhibitor, is unaltered or increased in hypoxia, thereby altering the noggin to BMP ratio and prohibiting bone formation. Consequently, application of small interfering RNA (siRNA) to suppress noggin may restore BMP activity to normal (normoxic) levels over the long-term, restoring the balance between BMPs and BMP inhibitors and ultimately increasing the rate of new bone formation.