Grants We Funded
In 2019, The Plastic Surgery Foundation (The PSF) awarded 33 investigator-initiated projects and allocated $891,274 to support the newest, clinically relevant research in plastic surgery.
The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area, or PSF funding mechanism.
The Effects of Modality Matching on Peripheral Nerve Regeneration
Thomas Tung MD
Basic Research Grant
Peripheral nerve injuries represent a significant source of morbidity and disability in the United States and abroad. When end-to-end repair is not possible, autologous nerve grafting remains the preferred method for reconstruction of nerve gaps. Such grafts are typically taken from superficial sensory nerves, such as the medial antebrachial cutaneous or sural nerves, in an effort to minimize donor-site morbidity. Though sensory nerves have long been assumed to be a suitable substrate for motoneuron regeneration, the limited functional recovery achieved with grafting compared to end-to-end repair suggests otherwise. A growing body of experimental evidence suggests that axonal regeneration improves when motor nerve gaps are reconstructed with motor grafts, and likewise for sensory. Termed modality-specific regeneration (MSR), this phenomenon seems to challenge the existing clinical dogma of repairing motor defects with sensory grafts. However, previous experiments demonstrating MSR utilized nerve grafts constructed of multiple cables or taken from spinal roots, which are not representative of nerve reconstructions performed in human patients. In our proposed study, we seek to demonstrate MSR in a more clinically relevant scenario. We hypothesize that matching of motor or sensory modality between donor and recipient nerves results in enhanced axonal regeneration. In order to more closely replicate nerve grafting as performed in human patients, our study will utilize only single-cable peripheral nerve grafts without the use of spinal roots. Our design also incorporates a more extensive analysis of grafted nerves than in prior studies, including retrograde labeling, stereology, and electron microscopy. If borne out by this study, modality matching of nerve grafts has the potential to significantly alter the practice of peripheral nerve reconstruction and enhance the clinical outcomes achieved in the nerve-injured patient.