Grants We Funded
Grant applicants for the 2022 cycle requested a total of over $2.9 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 115 grant applications on the following topics:
The PSF awarded research grants totaling almost $550,000 to support 19 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Targeted Gene Silencing Using siRNA Improve Diabetic Wound Healing
Vishal Thanik MD
New York University Medical Center
Basic Research Grant
The ability to affect gene expression via topical therapy has profound therapeutic implications for dysfunctional wound healing. Specifically targeting local gene expression topically avoids systemic toxicity and simplifies treatment. We have recently developed a novel method of topical gel-based siRNA application to precisely and effectively silence local gene expression in non delimited areas. In this project we will employ this technology to treat non-healing and slow healing diabetic wounds. Recent work has begun to elucidate the multiple genetic aberrations in this disease state that lead to dysfunctional wound healing. Two particularly interesting derangements in the diabetic state that may contribute to alter wound healing are dysregulation of the apoptotic pathways and berated matrix metalloproteinase (MMP) activity in the wound bed. We propose that by silencing various genetic targets, we will be able to restore normal gene patterning and in-turn, normal wound healing. To accomplish this, we will utilize a novel, topical gel based matrix to deliver small interfering RNA directly to the wound bed, allowing for local gene modulation without systemic effects.