Grants We Funded
Grant applicants for the 2023 cycle requested a total of nearly $4 million dollars. The PSF Study Section Subcommittees of Basic & Translational Research and Clinical Research evaluated nearly 140 grant applications on the following topics:
The PSF awarded research grants totaling over $1 million dollars to support nearly 30 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Research Abstracts
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Human Adipose Derived Adult Stem Cells as an Engineered Bone Substitute for Segmental Osseous Defects
Kurtis Moyer MD
2006
Duke University
Basic Research Grant
Tissue Engineering
Our laboratory is currently involved in engineering a bone substitute, which can be utilized to repair segmental osseous defects. Utilizing a biologic scaffold seeded with autologous adipose-derived adult stem (ADAS) cells we hypothesize that these ADAS cells will colonize the bone matrix and differentiate into osteoblasts accelerating incorporation of the allograft into the host skeleton. This may reduce the complications associated with conventional bone allografts. The assembly and surgical implantation of such a construct is expected to be simpler than conventional vascularized bone transfer methods and will permit its use at medical facilities outside major medical centers. This technique may reduce amputation and complication rates in patients who otherwise have no access to technically demanding reconstructive surgery. To achieve the long-term goal of creating an engineered bone substitute capable of immediate mechanical support, it will be necessary to deliver viable osteoprogenitor cells to the defect for osseo integration. In order to assure the viability of these oseoprogenitor cells it is necessary to understand the metabolic requirements of the implanted cells. Therefore the aim of this proposal is to characterize the metabolic requirements and their effects on the differentiation capacity of human adipose-derived adult stem (ADAS) cells. The results of this study will allow for the development of techniques designed to maximize the viability and utility of implanted ADAS cells for bone and other tissue engineering applications.