The Plastic Surgery Foundation
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Grants We Funded

Grant applicants for the 2022 cycle requested a total of over $2.9 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 115 grant applications on the following topics:

The PSF awarded research grants totaling almost $550,000 to support 19 plastic surgery research proposals.

ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.

Research Abstracts

Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.

Role of Egr1 in Skeletal Muscle Ischemia-Reperfusion Injury

Principal Investigator
Jamie Schall MD

Year
2005

Institution
Southern Illinois University

Funding Mechanism
Basic Research Grant

Focus Area
Technology Based

Abstract
Skeletal muscle is one of the most sensitive tissues to ischemic injury and the success of free flap and replantation surgery is dependent on the survival of this tissue following brief periods of ischemia. Tissue injury subsequent to ischemia-reperfusion (IR) insults is thought to be due to a cascade of cellular events that ultimately destroy skeletal muscle cells. While many of the cellular events of this cascade have been described, the molecular events that initiate this destructive cascade have not been elucidated in skeletal muscle tissue. The transcription factor early growth response protein-1 (Egr1) is a crucial mediator of inflammatory gene expression and has been shown to regulate IR injury in various organ models of IR injury. We propose that Egr1 contributes to skeletal muscle IR injury and will test this hypothesis using mice lacking a single copy or both copies of the Egr1 gene (Egr1 heterozygous, +/- and homozygous, -/- mice, respectively; Taconic). Further understanding of the mechanisms involved in mediating the effects of IR injury in skeletal muscle will aid in our ability to create a positive environment for muscle survival during procedures requiring free flap and replantation surgeries.