Grants We Funded
In 2019, The Plastic Surgery Foundation (The PSF) awarded 33 investigator-initiated projects and allocated $891,274 to support the newest, clinically relevant research in plastic surgery.
The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area, or PSF funding mechanism.
Mechanisms of Radiation Injury and Cytoprotechton in Osteoblasts
Artur Gevorgyan MD
Hospital for Sick Children
Cranio/Maxillofacial/Head and Neck
Our laboratory was the first to establish the rabbit orbito-zygomatic complex as a reliable and replicable model for studying craniofacial bone growth inhibition following therapeutic radiation (O'Donovan, et al. 200 I) and to demonstrate the efficiency of cytoprotection in its prevention (Forrest, et al. 2002). The purpose of the current study is to investigate the molecular and genetic mechanisms of radiation damage to osteoblasts in vitro and the efficiency of cytoprotection with WR-1065, the active metabolite of Amifostine (Capizzi, 1999), in MC3T3-E, mouse osteoblastic cell line. We hypothesize that (I) inhibition of osteoblast function following radiation occurs in a dose dependent way; (2) cytoprotection with WR-I 065 prevents radiation-induced inhibition of osteoblast function; (3) the mechanism of cytoprotection lies in cell cycle arrest, inhibition of apoptosis and activation of p53.