The Plastic Surgery Foundation
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Grants We Funded

In 2019, The Plastic Surgery Foundation (The PSF) awarded 33 investigator-initiated projects and allocated $891,274 to support the newest, clinically relevant research in plastic surgery.

The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.

Research Abstracts

Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area, or PSF funding mechanism.

VEGF Upregulation by HBO in Ischemia/Reperfusion

Principal Investigator
Richard Baynosa MD

Year
2004

Institution
University of Nevada

Funding Mechanism
Basic Research Grant

Focus Area
General Reconstructive

Abstract
Hyperbaric oxygen (HBO) inhibits ischemia-reperfusion (IR) induced neutrophil-ICAM adherence by preventing polarization of expressed surface CD18 molecules through a nitric oxide (NO) mediated pathway. The hypothesis of this project is: 1) to determine if the effect of HBO on systemic NO production is through upregulation of vascular endothelial growth factor (VEGF) mRNA and 2) to determine if the increase in VEGF results in increased activity of NOS. Specific Objectives: 1. To use rt-PCR to evaluate the differences in upregulation of VEGF mRNA between Sham, IR, IR-HBO and Sham-HBO tissue. 2. To use a radioactive assay to evaluate the differences in NOS activity between Sham, IR, IR-HBO and Sham-HBO tissue. 3. To use a monoclonal antibody to block VEGF and repeat the radioactive NOS activity assay to determine if the differences in NOS activity between Sham, IR, IR-HBO and Sham-HBO tissue are affected. This research should provide insight into the mechanisms of HBO in IR injury, which could significantly impact limb salvage and could have even broader implications in the treatment of IR injury in other organ systems.

Biography
Richard Baynosa, MD is an Assistant Professor of Plastic Surgery and the Associate Program Director for the plastic surgery integrated training program at the University of Nevada School of Medicine in Las Vegas. Dr. Baynosa received his undergraduate degree at UCLA followed by his medical degree from the UCSD School of Medicine. He completed an integrated plastic surgery residency at the University of Nevada School of Medicine including two years of basic science research primarily focused on hyperbaric oxygen mechanisms and ischemia-reperfusion injury. Dr. Baynosa has completed fellowship training in both hand and microsurgery as well as breast and aesthetic surgery. He then travelled to Belgium and Gent University Hospital to complete a fellowship in perforator flap and super-microsurgery under Philip Blondeel, MD. Dr. Baynosa is currently the Medical Director for the University Medical Center of Southern Nevada’s Advanced Wound Healing and Hyperbaric Medicine Center, where he serves on numerous local and national committees. He has authored several book chapters and articles and has presented his work at numerous local and national scientific meetings.