The Plastic Surgery Foundation
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Grants We Funded

In 2019, The Plastic Surgery Foundation (The PSF) awarded 33 investigator-initiated projects and allocated $891,274 to support the newest, clinically relevant research in plastic surgery.

The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.

Research Abstracts

Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area, or PSF funding mechanism.

Induction of Oxidative Stress to Promote Angiogensis

Principal Investigator
Lisa Gould MD

Year
2003

Institution
University of Texas

Funding Mechanism
Basic Research Grant

Focus Area
Tissue Engineering

Abstract
Regardless of etiology, a common feature of chronic wounds is tissue ischemia and its sequelae. This is compounded in elderly individuals who have poor tissue perfusion due to peripheral vascular disease or heart disease. Induction of angiogenesis in the ischemic wound bed is critical for tissue repair. Both hypoxia and hyperoxia have been shown to induce angiogenesis, yet the mechanism whereby these two opposing stimuli can produce the same result remains obscure. We will utilize the aortic ring assay to test the hypothesis that both hypoxia and hyperoxia induce oxidative stress, resulting in a series of molecular signals that promote angiogenesis. This ex vivo assay is well established in our laboratory and is well suited for studying the molecular mechanisms of angiogenesis. Upon completion of this proposal we will have identified the molecular pathway(s) used in redox sensitive signaling. Further resolution of the mechanisms of oxygen sensitive signal transduction will lead to strategies, such as gene therapy, to induce angiogenesis in the wound bed.