Grants We Funded
Grant applicants for the 2023 cycle requested a total of nearly $4 million dollars. The PSF Study Section Subcommittees of Basic & Translational Research and Clinical Research evaluated nearly 140 grant applications on the following topics:
The PSF awarded research grants totaling over $1 million dollars to support nearly 30 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Research Abstracts
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Age-Associated Differences in Adipose-Derived Mesenchymal Stromal Cells
Yun-Ying Shi
2003
Stanford University
Basic Research Grant
Tissue Engineering
Since the late 1800s, many methods for reconstructing non-ossifying adult calvarial defects have been developed. Yet, the search for the source of donor materials continues. Recent findings have suggested that adipose tissue, capable of in vitro adipogenic, osteogenic, chondrogenic, and neurogenic differentiation, could contain multi potent stromal progenitor cells. These findings opened new possibilities for reconstruction of calvarial defects using tissue engineering and cell-based therapies. While much interest has been generated over the multilineage potential of these adipose-derived mesenchymal stromal cells (ADMSCs), very little is known about the effect of tissue donor age on the biology or function of ADMSCs. We hypothesize that juvenile and adult ADMSCs have different biologic profiles and thus different abilities to re-ossify calvarial defects. In the first Specific Aim, we will determine the differences in the molecular biology of juvenile and adult ADMSCs undergoing osteogenesis differentiation. Alterations in osteogenic gene expression will be assessed using micro array technology and quantitative, real-time RT-PCR. In the Second Specific Aim, we will utilize an established mouse critical size calvarial defect model to determine the ability of juvenile and adult ADMSCs to re-ossify critical size calvarial defects. The research proposed in this application will help to direct future strategies in cell-based therapies for calvarial healing. This will facilitate the development of novel, clinically applicable techniques with which to reconstruct non-healing calvarial defects.