The Plastic Surgery Foundation
Log In Donate Now
 

Grants We Funded

In 2019, The Plastic Surgery Foundation (The PSF) awarded 33 investigator-initiated projects and allocated $891,274 to support the newest, clinically relevant research in plastic surgery.

The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.

Research Abstracts

Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area, or PSF funding mechanism.

Tissue Engineered Bone in a Prefabricated Capsular Flap

Principal Investigator
Michael Neumeister MD, FRCSC, FACS

Year
2003

Institution
Southern Illinois University

Funding Mechanism
Basic Research Grant

Focus Area
Tissue Engineering

Abstract
Using recent advances in tissue engineering and the principles behind the prefabrication of flaps, this research will compare various methods of bone formation in a capsular flap. The ultimate goal is to provide a technique to reconstruct bony defects by using a composite tissue flap engineered at a distant location and in a specific shape and then transferred to the site of the defect, thereby minimizing donor site morbidity and avoiding the limitations presented by a finite supply of autogenous bone available for grafting. From previous experiments on prefabrication and prelamination of different cell types, including urothelial cells, tracheal epithelial cells, and chondrocytes, we have found that transposing a vascular pedicle to a subcutaneously placed silicone block will result in a vascular capsule, that can be mobilized and transferred based solely on the pedicle. The capsule provides the necessary blood supply for cell growth. No study to date has investigated osteoinduction in a prefabricated vascularized capsular flap. In a clinical setting, this technique may provide another option in reconstruction of bony defects of the upper and lower extremities and the mandible due to trauma, tumor resection, or congenital abnormalities. The use of the patient's own bone marrow or adipose tissue as sources for cultured mesenchymal stem cells may represent the best option for creating new bone in the prefabrication of flaps without the morbidity associated with the harvesting of autogenous bone graft and may also prove to be more reliable in the osteoinductive process than bone graft substitutes or genetically engineered products.

Biography
Dr. Neumeister is Professor and Chairman of both the Department of Surgery and Institute for Plastic Surgery at Southern Illinois University School of Medicine (SIUSOM). Dr. Neumeister has been the Director of the Wound Healing Center at the Memorial Medical Center (MMC) for over 12 years and Director of the Regional Burn Center at the Memorial Medical Center for over 6 years. His clinical practice includes all aspects of plastic surgery, including burn treatment, wound care, hand injuries, and cosmetic surgery. In addition to his clinical activities, Dr. Neumeister has received over $1,780,000 in grants for research projects, has made over 90 national presentations and has mentored over 100 resident and student research projects that have led to presentations over the past 11 years. His work has led to the publication of over 70 scientific publications and 12 book chapters.