Grants We Funded
Grant applicants for the 2022 cycle requested a total of over $2.9 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 115 grant applications on the following topics:
The PSF awarded research grants totaling almost $550,000 to support 19 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Immunogenicity of Chondrocytes Removed From Extracellular Matrix
Massachusetts General Hospital
Basic Research Grant
Normal cartilage is immunologically privileged by virtue of the absence of blood and lymphatic vessels. Chondrocytes that are embedded in lacunae within the extracellular matrix obtain nutrients through diffusion from the synovial fluid in the joint cavity but are excluded from interacting with cells of the immune system by their protective extracellular matrix. Under pathologic conditions, cartilage cells are exposed and can interact with lymphocytes and other cells present in the synovial tissue and fluid. For example, human articular cartilage chondrocytes from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) express class II major histocompatibility (MHC) antigens, a potent activator of immune cells. These antigens are not known to be expressed in the absence of pathology, and their presence in RA/OA may underlie an immune response to exposed chondrocytes in these conditions. As the potential for tissue engineering approaches expands for cartilage repair, chondrocytes can be transplanted across syngeneic, allogeneic and xenogeneic barriers. During the process of engineering cartilage, chondrocytes are removed from their native immunoprotective matrix and the cell surface antigens are exposed to immunologic or antigen-presenting cells. This may lead to immune reaction against the naked chondrocytes, which may lead to pathologic conditions like those associated with arthritis. However, little is known about the expression of MHC molecules (class I or II) in engineered cartilage and their propensity to stimulate an immune response by the host. Our laboratory has extensive experience in the field of tissue engineering cartilage using swine chondrocytes obtained from various anatomical sites (e.g. articular joints, ribs, ears, etc.) and encapsulated in biological or synthetic hydrogels. The Transplantation Biology Research Center (TBRC) of the Massachusetts General Hospital has developed a unique population of swine in which the immunogenetics have been mapped in order to perform well-controlled organ and tissue transplantation studies in a large animals. We propose to use these swine and the numerous cell-marker antibodies available to study the immunogenicity of chondrocytes in large animals that will serve as a valuable preclinical cartilage repair model.