The Plastic Surgery Foundation
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Grants We Funded

Grant applicants for the 2021 cycle requested a total of over $3.3 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 106 grant applications on the following topics:

The PSF awarded research grants totaling more than $755,000 to support 25 plastic surgery research proposals.

ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.

Research Abstracts

Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.

The Biophysical Properties of Composite Flexor Tendon Allografts

Principal Investigator
Brent Degeorge Jr., MD, PhD

Year
2013

Institution
The Rector and Visitors of the University of Virginia

Funding Mechanism
Pilot Research Grant

Focus Area
Hand or Upper Extremity, Tissue Engineering

Abstract
Volar hand injuries with marked soft tissue loss, including specifically the pulley system and the flexor tendon structures, pose a unique problem to the reconstructive hand surgeon. Even with optimum surgical treatment and physical therapy, a significant portion of these individuals are plagued by chronic pain, stiffness, and decreased range of motion, which are associated with significant loss of vocational capacity and quality of life. The gold standard for repair of these injures continues to be primary repair, however when the amount of tissue loss is too great, this is not achievable. Innovative operative techniques are required to restore both form and physical function to this patient population. Herein, we describe a novel reconstructive approach to volar hand injury with significant soft tissue loss through the use of composite flexor tendon allografts (CFTAs) consisting of intrasynovial flexor tendon and associated pulley structures and fibro-osseous sheath with intact volar plates and periosteum as a single functional unit with a distal bone attachment. The overall hypothesis of our work is that CFTAs possess unique properties which may allow for decreased cicatricial scar through the pulley system, improved tendon gliding, and decreased need for multiple operative procedures and donor site morbidity compared with conventional multi-stage silastic rod tendon reconstruction. This approach represents an important step towards designing an ideal material for complex flexor tendon reconstruction, which takes advantage of an intrasynovial flexor tendon in its native fibro-osseous sheath without the need for additional donor morbidity using a construct which can be engineered to have minimal tissue reactivity, negligible potential for disease transmission, and improved tendon healing properties versus standard tendon allograft.

Biography
Dr. DeGeorge graduated summa cum laude from The College of William and Mary and attended Jefferson Medical College / Thomas Jefferson University where he completed his medical education and a Ph.D. in Molecular Pharmacology and Structural Biology. He completed residency training in the Department of Plastic Surgery at the University of Virginia and fellowship training in Hand and Microvascular Surgery in the Department of Orthopedic Surgery at the Mayo Clinic. He has returned to the University of Virginia as an Assistant Professor and member of the Hand Division. His areas of expertise include brachial plexus and peripheral nerve surgery and hand, wrist, and forearm reconstruction following trauma. His research interests include outcomes studies and regeneration techniques and allograft tendon, cartilage, and dermis engineering. He has previously received funding from the Plastic Surgery Foundation, Southeastern Society of Plastic and Reconstructive Surgeons, and the American Heart Association. He was selected in 2017 into the AAOS/OREF/ORS Clinician Scholar Career Development Program. This proposal represents a component of his research program being prepared for a NIH Research Career Development Award.