Grants We Funded
Grant applicants for the 2021 cycle requested a total of over $3.3 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 106 grant applications on the following topics:
The PSF awarded research grants totaling more than $755,000 to support 25 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Terminal Schwann Cells: Roles in Development and Regeneration
Alison Snyder-Warwick MD
Washington University in St.Louis
Pilot Research Grant
Peripheral nerve injuries can be devastating. Clinical management of peripheral nerve injuries is limited temporally, resulting in permanent paralysis or functional limitation. The molecular mechanisms responsible for this limitation are not known. Many investigations have focused on neuroregeneration or on myelinating Schwann cells located along the nerve axon, but additional understudied components of the nerve-synapse-muscle relationship may hold functional significance.
The peripheral nervous system (PNS) is supported by two main categories of glial cells: myelinating and non-myelinating Schwann cells. Non-myelinating Schwann cells in the PNS include Remak cells along the axon and terminal Schwann cells at the synapse. Non-myelinating Schwann cells display functional plasticity providing guidance, trophic support, and regenerative assistance to neurons and may provide critical opportunities for therapeutic benefit. Investigation of the non-myelinating lineage, however, has been limited by few specific molecular makers and tools for study.
An orphan G protein-coupled receptor, Gpr126, is essential for myelinating Schwann cell development. Gpr126 mutant mice display abnormalities not only in the myelinating lineage, but also in Remak Schwann cells, motor nerve, and muscle morphology. We hypothesize that Gpr126 is essential for terminal Schwann cell development, but this has not been investigated. As a G protein-coupled receptor, Gpr126 represents an excellent therapeutic target for stimulating repair in patients with peripheral nerve injury. The goal of this study is to define the function of Gpr126 in terminal Schwann cell development at the neuromuscular junction.
In this study, we focus on evaluating the roles of terminal Schwann cells in development and reinnervation. In the first aim, we will define the terminal Schwann cell phenotype in Gpr126 mutant mice with immunostaining and electron and confocal microscopy at different developmental time points. In the second aim, we will test the hypothesis that terminal Schwann cells are necessary for muscle reinnervation following injury in both cranial and peripheral nerve models via laser ablation of these cells. Together, these studies will provide important initial data on terminal Schwann cell development, function, and molecular signaling, which could potentially provide important clinical therapeutic interventions following nerve injury. Modification of terminal Schwann cell function and signaling may provide a key to prolonging the critical window during which muscle reinnervation can occur or protecting injured muscle from degenerative effects following denervation.
Dr. Alison Snyder-Warwick is an Assistant Professor of Surgery, Division of Plastic Surgery, and the director of the Facial Nerve Institute at Washington University in St. Louis. She specializes in management of facial paralysis in children and adults, obstetrical brachial plexus reconstruction and pediatric plastic surgery. Her clinical interests inspire innovative basic science research involving terminal Schwann cells, unique cells present at the nerve-muscle interface, which may have an important role in recovery after nerve injury. Dr. Snyder-Warwick completed her medical school and general surgery residency training at Washington University in St. Louis. She completed a research fellowship in Developmental Biology in the laboratory of Dr. David Ornitz before finishing her plastic surgery residency training at Washington University. Dr. Snyder-Warwick then traveled to Toronto, Canada for specialized training in pediatric plastic surgery and microsurgery at the Hospital for Sick Children. Dr. Snyder-Warwick specializes in pediatric plastic surgery and microsurgery. Her research interests focus on the significance of terminal Schwann cells in differing environments. She is Secretary of the Sir Charles Bell Society, an international, multidisciplinary group dedicated to the advancement of treatment for facial nerve disorders. Dr. Snyder-Warwick is committed to studying novel techniques of optimizing care for people affected by peripheral nerve injuries.