Grants We Funded
In 2018, The Plastic Surgery Foundation (The PSF) awarded 33 investigator-initiated projects and allocated $891,274 to support the newest, clinically relevant research in plastic surgery.
The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area, or PSF funding mechanism.
A Novel Osteogenic Oxysterol for Cranial Bone rRegeneration
Reza Jarrahy MD
The Regents of the University of California, Los Angeles
National Endowment for Plastic Surgery Grant
Craniofacial defects from congenital deformity, trauma, or tumor resection affect hundreds of thousands of individuals in the United States annually, representing a significant financial burden. Autologous bone and alloplastic materials are the mainstay of surgical treatment for complex craniofacial
deformities, but these approaches have significant drawbacks. Bone graft substitutes using bone morphogenetic proteins (BMPs) have been heralded as potential alternatives to reconstruction. BMP-based products, however, are associated with significant and potentially life-threatening side effects when used in the head and neck, and are exorbitantly priced. By comparison, oxysterols are products of cholesterol oxidation with proven osteoinductive capacity in mouse, rabbit, and human mesenchymal stem cells lines. Oxysterols are favorable alternatives or adjuncts to BMP therapy due to their low side effect profile and cost. As a cooperative of surgeons and scientists, we believe that oxysterols—by limiting the amount of BMP needed in a bone graft substitute paradigm—will advance the field of bone regeneration through cost reduction and improved care without any compromise in outcomes. Our preliminary data shows that Oxy133—a novel oxysterol robustly stimulates osteogenesis in vitro in rabbit MSCs. We propose to test the clinical relevance of this osteogenic activity with a series of in vivo studies. First we will reconstruct criticalsized rabbit calvarial defects by Oxy133-embedded collagen scaffolds. Using the Hedgehog (Hh) pathway inhibitor cyclopamine, we will then examine the role of Hh signaling in Oxy133-induced bone formation. We anticipate that Oxy133 will stimulate bone formation in vivo through activation of Hh pathway signaling. Finally, we anticipate the addition of autologous rabbit BMSCs will further enhance Oxy133-mediated bone regeneration in vivo. Findings from our proposed studies will support a new model for safe, quality, and cost-effective bone regeneration of craniofacial defects.
Reza Jarrahy, MD, FACS, FAAP is a board-certified plastic surgeon who has served on the full-time faculty of the David Geffen School of Medicine at UCLA since 2007. He specializes in craniofacial reconstructive surgery in children and adults, pediatric plastic surgery, and in cosmetic and surgery of the face and body. He is Co-Director of the UCLA Craniofacial Clinic, Co-Director of the UCLA Face Transplant Program, and Assistant Chief of Plastic Surgery at Olive View-UCLA Medical Center. Dr. Jarrahy earned his B.S. in Biology from Stanford University (1992) and his M.D. from SUNY Stony Brook (1996). He completed his plastic surgery residency and craniofacial surgery fellowship at UCLA. In addition to his clinical work, Dr. Jarrahy also directs a productive research laboratory which focus on tissue engineering research and clinical research relevant to craniofacial surgery and other fields in plastic surgery. He is the recipient of numerous research awards and grants and the author of many scientific publications, abstracts, and book chapters. He serves on the Board of the American Society of Maxillofacial Surgeons, contributing to national educational programs in craniofacial surgery. Dr. Jarrahy also regularly travels overseas to provide free reconstructive surgery to children in developing nations.