Grants We Funded
Grant applicants for the 2022 cycle requested a total of over $2.9 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 115 grant applications on the following topics:
The PSF awarded research grants totaling almost $550,000 to support 19 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Seeding Success: Encouraging Cross-Talk At The Vascular Frontline
Marc Soares MD
New York University School of Medicine
Pilot Research Grant
Composite Tissue Allotransplantation, Tissue Engineering
The endothelial barrier is the frontline defense of the vascular network; it is the backbone of a tightly regulated gateway that controls nutrient/waste delivery, fluid balance, host defenses, and ultimately, tissue survival. Unfortunately, the failure of this gateway represents a common feature within many clinical challenges of plastic surgery, including chronic wounds, tissue edema, ischemia-reperfusion injury, flap failure, and even allograft rejection. Currently, there are few strategies to improve endothelial integrity; treatment focuses solely on combating the overarching pathology. Preliminary data by our lab suggest that mesenchymal stem cells (MSCs) can protect the vascular network. We propose that MSC-seeded vasculature can effectively mitigate endothelial injury in in-vitro and in-vivo models of ischemia-reperfusion and immune-mediated rejection. We further intend to demonstrate that this vasculoprotective effect occurs through synergistic crosstalk between endothelial cells and MSCs. Strategies to protect the vasculature at the time of (or prior to) cytotoxic injury represents a paradigm shift in the use of MSCs in regenerative medicine, and has direct clinical applicability in reconstructive microsurgery, composite tissue allotransplantation, and tissue engineering.
Marc Soares, MD was born and raised in Santa Barbara, CA. He received his undergraduate degrees from MIT in chemical engineering and biology, followed by a medical degree from Cornell University. Dr. Soares is currently in the middle of his plastic surgery training at the Institute of Reconstructive Plastic Surgery at the New York University Medical Center, where he is electively pursuing a two-year, post-doctoral research fellowship. His past and present research interests include bioassay design, stem-cell biology, and applying tissue-engineering approaches to clinical problems. Under the mentorship of Drs. Daniel Ceradini, MD and Pierre Saadeh, MD, he is exploring novel ways to use mesenchymal stem cells to support vascular function in the setting of hypoxia and allotransplantation.