The Plastic Surgery Foundation
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Grants We Funded

In 2019, The Plastic Surgery Foundation (The PSF) awarded 33 investigator-initiated projects and allocated $891,274 to support the newest, clinically relevant research in plastic surgery.

The American Society of Plastic Surgeons/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.

Research Abstracts

Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area, or PSF funding mechanism.

Studying Breast Implant-Associated ALCL in Three-Dimensional Organotypic Platform

Principal Investigator
Jason Spector MD

Year
2019

Institution
Joan & Sanford I. Weill Medical College of Cornell University

Funding Mechanism
Pilot Research Grant

Focus Area
Breast (Cosmetic / Reconstructive), Tissue Engineering

Abstract
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare but serious potential complication of device-based breast implantation. If caught early, the disease is largely treatable, but severe cases may recur or even lead to death. The exact cause of BIA-ALCL remains unclear, and successful methods of prevention have yet to be developed. The purpose of the present study is to utilize our advanced, three-dimensional in vitro organotypic breast tissue platform for studying the mechanisms underpinning BIA-ALCL. This platform incorporates patient-derived breast tissue which has been processed for cellular components including fat, vascular, glandular, and immunologic cells into a three-dimensional matrix of type 1 collagen, thereby allowing for a high-fidelity recreation of the true breast microenvironment in which cell behavior can be studied. Specifically, a patient-derived line of BIA-ALCL cells will be studied within the platform, and endpoints such as cell growth, invasion, and cell signaling expression will be analyzed both with and without pieces of breast implant incorporated into the platform. The goal of these experiments is to focus on the role played by breast implant materials (both smooth and textured) in the development and progression of BIA-ALCL. In order to achieve this goal, the first aim of the study is to analyze the effect of altered matrix stiffness (via ribosylation or changes in concentration) on BIA-ALCL cell growth and invasion as this property has been shown to significantly affect the behavior of many other types of cancer cells. Next, we will utilize the platform to assess the behavior of the same established BIA-ALCL cell line with no implant, with smooth implant incorporated into the platform, and with textured implant incorporated into the platform. Cell growth and invasion will be assessed in addition to the signaling molecule, IL-6, and its receptor, IL-6R, as this cytokine has been shown in prior studies to be upregulated in clinical cases and in ex vivo models of BIA-ALCL. Such an analysis has the potential to contribute to the etiologic understanding of BIA-ALCL, and it lays the groundwork for future studies of BIA-ALCL within our high-fidelity, high-throughput, three-dimensional organotypic breast tissue platform which may lead to even further understanding of BIA-ALCL pathogenesis in addition to the potential development of ways to avoid this rare but deadly complication of breast implantation.

Biography
Dr. Jason Spector is a nationally recognized clinician, researcher and educator. He holds two patents, and has been an integral part several Cornell University-Weill Cornell Medical College translational research teams. He participates in the NIH and Howard Hughes Medical Institute sponsored Clinical Summer Immersion for Biomedical Engineering Program, mentoring engineering doctoral students. Since 2007, he has been a lecturer at Cornell University's Biomedical Engineering Science and Technology course, "Approaches to Problems in Human Needs." Dr. Spector serves as an Ad-Hoc reviewer for six prestigious medical journals, and has presented at national and international medical meetings. He recently served as Moderator of the Emerging Technologies Section, at the American Surgical Congress in 2011.