Grants We Funded
Grant applicants for the 2022 cycle requested a total of over $2.9 million dollars. The PSF Study Section subcommittees of Basic & Translational Research and Clinical Research evaluated 115 grant applications on the following topics:
The PSF awarded research grants totaling almost $550,000 to support 19 plastic surgery research proposals.
ASPS/PSF leadership is committed to continuing to provide high levels of investigator-initiated research support to ensure that plastic surgeons have the needed research resources to be pioneers and innovators in advancing the practice of medicine.
Search The PSF database to have easy access to full-text grant abstracts from past PSF-funded research projects 2003 to present. All abstracts are the work of the Principal Investigators and were retrieved from their PSF grant applications. Several different filters may be applied to locate abstracts specific to a particular focus area or PSF funding mechanism.
Evaluating Muscle Regeneration Using a Cell Enhanced Amniotic Membrane Allograft
Anand Kumar MD
Case Western Reserve University - School of Medicine
PSF/MTF Biologics Allograft Tissue Research Grant
Tissue Engineering, General Reconstructive
Project Summary: Volumetric muscle loss (VML) is associated with significant functional and aesthetic deficits. The current options for treatment of VML include acellular biological scaffolds (ACellR) and muscle/tendon transfers. These treatments are limited scarring or by donor site morbidity respectively. There remains an unmet need for functional muscle regeneration. Our group has developed, validated, and published a critical sized muscle defect capable of studying various collagen scaffolds including cell augmented scaffolds. Our approach takes advantage of the inherent heterogeneity of MDPCs, which contain both myogenic and angiogenic elements, for optimal skeletal muscle regeneration. In the proposed grant, we seek to test a cell enhanced amniotic membrane scaffold with florescent lineage specific cell tracking technology in our validated VML model. We expect to regenerate a greater volume of functionally polarized muscle with minimal fibrosis compared to collagen scaffolds. Additionally, we seek to further characterize the mechanisms of cell mediated tissue regeneration and defect repopulation using a novel florescent cell tracking technology (Rosa26-CAG-Brainbow2.1/Confetti derived cells). Impact Statement: Volumetric muscle loss (VML) is associated with significant morbidity in both civilian and military populations. Current treatments are limited and thus a translational regenerative solution that minimizes donor morbidity and regenerates functionally polarized tissue is timely and necessary. Our proposed research is an impactful and logical step forward towards our stated goal of healing VML defects and further the understanding of basic cellular repopulation mechanisms within the tissue defect using a florescent lineage specific cell tracking technology (Rosa26-CAG-Brainbow2.1/Confetti derived cells) within our murine model. These critical and sequential steps are necessary steps prior to pragmatic upscaling in a large animal model.
Anand R. Kumar, MD was recruited to Pittsburgh from Bethesda, MD, where he served as Director and Staff Pediatric Plastic Surgeon of the Military Craniofacial Unit at Walter Reed National Military Medical Center. He previously acted as Division Chief in Plastic and Reconstructive Surgery at the National Naval Medical Center in Bethesda. Dr. Kumar completed a fellowship in craniofacial surgery/pediatric plastic surgery at the University of California at Los Angeles. While in Los Angeles, Dr. Kumar also completed a residency in plastic and reconstructive surgery. He received additional training in general surgery at the Mayo Clinical Graduate School of Medicine; Rochester, MN. Dr. Kumar obtained his medical degree from Albert Einstein College of Medicine in Bronx, NY. His clinical practice focuses on craniofacial surgery including the correction of pediatric and adolescent facial skeletal deformities and airway obstruction using traditional orthognathic surgery and distraction osteogenesis. His basic science research is focused on combat casualty care related to heterotrophic bone formation and harnessing its potential for structural bone regeneration.